Microbiota and the brain-gut connection
Written by Stefanie Twist
Reviewed by Dr. Premsyl Bercik
In the past few years, attention devoted to microbiota and the brain-gut connection has increased. Gut microbiota encompasses the bacterial colonies, fungi, viruses, and other microbes that live within our gastrointestinal tract.(1, 2) Importance of bacteria in our GI tract should not be understated as they contribute to key biological processes in our body. However, when there are changes to this balance, it can be the reason symptoms develop.
Microbiota development starts at birth. Factors such as vaginal versus cesarean birth and breastfeeding versus formula shape the diversity and proliferation of strains of bacteria.(2, 3) Human breastmilk has nutrients which can help shape the microbiome and immune development of children. Infant’s initial exposure to microbiota is through the act of birth. Cesarean section births correlated with increased risk of children developing celiac disease, asthma, type 1 diabetes, and obesity.(4) This may occur because infants born vaginally are exposed to their mother’s vaginal microbiota while those born via cesarean are not.
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A Message from the ANMS President John Pandolfino, MD
It is both a privilege and honor for me to assume the role of President of the American Neurogastroenterology and Motility Society and to continue to work with an exceptional group of staff, councilors and officers. This is an unprecedented time in our history for both our society and our global community as we deal with a world-wide pandemic, and begin to truly address many of the inequities that have plagued society and our academic culture. I am humbled by this opportunity, and believe the ANMS can make a substantial contribution by addressing these issues head-on, and evolving into a new academic society focused on collaboration and developing deep ties to our community.
I have been involved with the ANMS since I was a trainee, and have been in a continuous leadership role since 2012 when I was elected to council, and subsequently became treasurer and president-elect. Over this time, I was fortunate to work with multiple presidents, such as Drs. Beverley Greenwood-Van Meerveld, Gianrico Farrugia, John Wiley, and Lin Chang. Happily, I will be able to continue to work with Drs. Beverley Geenwood-Van Meerveld and John Wiley, as they help solidify the future of the ANMS with their leadership roles in the ANMS Institute. Dr. Greenwood-Van Meerveld will take over as Director of the Institute, and Dr. John Wiley will remain as an advisor to the Institute, to maintain a strong continuity with our industry partners.
Over the last four years, we have also had an amazing team of ANMS councilors, and we are always sad to see exceptional people rotate off council. I would personally like to thank Drs. Miranda van Tilburg, William Chey, Elyanne Ratcliffe, and Purna Kashyap for their amazing contributions to the ANMS. These councilors have helped our society develop an amazing social media presence, an exceptional grant process to fund young investigators, and an excellent series of cutting-edge educational programs. These projects have showcased the important role ANMS has taken in educating and training our members and the next generation of leaders. This great work will continue with our remaining councilors: Drs. Jose-Garza, Simon Gibbons, Baharak Moshiree, and Linda Nguyen, and our newly elected councilors: Drs. Jason Baker, Katja Kovacic, David Levinthal, Eamonn Quigley, Shanthi Srinivasan, and Gregory Sayuk. I would also like to congratulate Dr. Nicholas Verne for his election as the new President-Elect and Dr. Fedias Christofi, who will assume the role of Treasurer. Last, Dr. C. Prakash Gyawali will transition from his role as councilor and continue his work as an ex-officio member focusing on our Clinical Training Program and curriculum development with our global sister societies. I look forward to working with them over the next two years in my role as president.
2023 ANMS Annual Meeting
Date: August 11-13, 2023
Clinical Course: Providing the best clinical care for our patients
Scientific Meeting: Advancing patient care through cutting edge research
ANMS Young Investigator Forum – August 9-10, 2023
ANMS Fellows Advancing Motility Meeting (for 2nd and 3rd year fellows) – August 10, 2023
Abstract Deadline: April 1, 2023 (by midnight EST)
Registration and Further information will be forthcoming
Location: Austin, Texas
2022-2023 ANMS Virtual Webinar Schedule for both Clinical, Basic Science, and Medical Procedure Education Series
ANMS Virtual Symposia: Basic Medical Procedure Education Series on Pearls of Wisdom: Hydrogen Breath Testing
February 15, 2023 – 6 pm ET/5 pm CT/3 pm PT
Moderators: Jason R. Baker, PhD and Brooks D. Cash, MD
Pearls of Wisdom: Hydrogen Breath Testing
Speaker: Coka Yip, NP, Cedars-Sinai Medical Center
Click here to Register
ANMS Basic Concepts Virtual Symposium: What‘s behind the positive effects of neuromodulation on gut function?
January 11, 2023 – 6 pm ET/5 pm CT/3 pm PT
Moderators: Kenneth Koch, MD and Jennifer Wellington, DO
Transcutaneous auricular vagal nerve stimulation improves functional dyspepsia by enhancing vagal efferent activity, Jiande Chen, PhD, University of Michigan
The effect of gastric electrical stimulation and gastric mapping on small bowel motility in patients with gastroparesis and concomitant pancreatic and small bowel dysfunction, Thomas L. Abell, MD University of Louisville
Click here to register
December 7, 2022 – 6 pm ET/5 pm CT/3 pm PT
Moderator: Baha Moshiree, MD and Emily Haller, MS, RDN
Establishing a successful Doctor-Patient partnership from Doctor perspective, Kenneth Koch, MD, Wake Forest University’s School of Medicine and Atrium Health Wake Forest Baptist
Establishing a successful Patient-Doctor partnership from Patient perspective – Laura A. Dotson, Laura A. Dotson, BA, BS, MAT, Patient Advocate and Educator
Click here to view on ANMS YouTube
Pearls of Wisdom: Colon Manometry
December 14, 2022 – 6 pm ET/5 pm CT/3 pm PT
Moderators: Jason R. Baker, PhD and Lusine Ambartsumyan, MD
Speaker: Lisa Sitz, NP, Children’s Healthcare of Atlanta
Click here to view on ANMS YouTube
Pearls of Wisdom: GI Nuclear Scintigraphy
October 12, 2022 – 6 pm ET/5 pm CT/3 pm PT
Moderators: Jason R. Baker, PhD and Henry Parkman, MD
Speaker: Duane Burton, MHA, Mayo Clinic, Rochester
View on ANMS YouTube
Basic Science Webinar Theme: Basic Concepts in Neurogastroenterology
Neuroimmune Interactions in the GI tract
Wednesday, October 19, 2022 – 9 am PT/11 am CT/12 pm ET
Moderators: Kara Margolis, MD and Gianluca Cipriani, PhD
Immune mechanisms of enteric nervous system remodeling: linking IBD to IBS
Milena Bogunovic, MD, PhD, UMass Chan Medical School
Regulation of intestinal immunity and tissue repair by enteric glia
Fränze Progatzky, PhD, The Francis Crick Institute
Click here to register
What are the basic mechanisms underlying the impact of diet on symptoms of IBS?
Wednesday, November 16, 2022 – 9 am PT/11 am CT/12 pm ET
Moderators: William Chey, MD and Bethany Doerfler, MS, RD, LDN
Guy E. Boeckxstaens, MD, PhD KU Leuven / UZ Leuven
Local immune response to food antigens drives meal-induced abdominal pain
Stephen Vanner, MSc, MD, Queen’s University
Nutritional profile of rodent diets impacts experimental reproducibility in microbiome preclinical research
Click here to View on ANMS YouTube
Clinical Theme: Better Together: Bridging the Divide Between Pediatrics and Adult GI Motility Disorders
Why can’t we fix Gastroparesis?
Co-sponsored by Neurogastrx
August 24, 2022 – 6:00 pm ET/5:00 pm CT/3:00 pm/PT
Moderator: Linda Nguyen MD
Gastroparesis drug trials: why have they failed?
Brian E. Lacy, PhD, MD, Mayo Clinic, Jacksonville
How to treat Gastroparesis in Children. Are the current guidelines appropriate?
Katja Kovacic, MD, Medical College of Wisconsin
View on ANMS YouTube
Small Intestinal Bacterial Overgrowth
Wednesday, March 9, 2022 – 6:00 pm ET/5:00 pm CT/3:00 pm/PT
Moderator: Baha Moshiree, MD
Clinical Pictures of SIBO
Eamonn Quigley, MD
Houston Methodist and Weill Cornell Medical College
Testing for SIBO
Lucinda Harris, MD
Mayo Clinic, Scottsdale
View on ANMS You Tube
The Mission and Goals of the ANMS
The American Neurogastroenterology and Motility Society is an organization that was established in 1980 dedicated to the study of neurogastroenterology and gastrointestinal motility and functional GI disorders.
Mission of the ANMS
To be the multidisciplinary society leading the field of neurogastroenterology by fostering excellence in research, education, training, and patient care.
Neurogastroenterology encompasses the study of brain, gut, and their interactions with relevance to the understanding and management of GI motility and functional GI disorders.
ANMS Condemns Racism, Injustice and Inequality
The ANMS condemns any cases of racism, injustice and inequality. As a scientific and medical society, the ANMS leadership would like to emphasize the importance of fostering justice, equity, diversity, and inclusion. We must dedicate ourselves to removing barriers that exclude historically marginalized persons from participation in our community.
As a multidisciplinary society leading the field of neurogastroenterology and motility we are better when fostering collaborations and supporting each other inclusive of race, ethnicity, gender, sexual orientation, religion and disability.
Start receiving YOUR benefits today:
Ironwood-ANMS Diversity Development Award
Award deadline: May 13, 2022 by midnight EST
Further information click here
5 years post terminal training (postdoc or fellowship)
ANMS Member for at least 2 years
Mid-career woman or under-represented gender or ethnic minority
Attend 2022 ANMS Meeting in Philadelphia (August 5-7, 2022)
This award is to help support talented mid‐career women or under‐represented gender or ethnic minority achieve academic promotion. The award(s) are open to all current ANMS members who are > 5 years post terminal training (postdoc or fellowship). Eligible ANMS members are invited to self-nominate.
The award funds can be used to support salary or travel for a mini‐sabbatical or professional development leave or bridge funding between grants to start or complete research projects. The recipient must attend the 2022 Annual ANMS meeting (August 5‐7, 2022 in Philadelphia, PA) to receive the award. The award will fund 1 grant for $20,000.
The Application can be downloaded at url below and will need to include:
* Letter of support from the applicant’s Division Chief or Department Chair
* If applying for Bridge funding we require an NIH style Biosketch.
Please format all materials as a single PDF and return via email to Lori Ennis at:
ANMS Discovery Grants Program
ANMS will be offering up to 2 grants – Deadline: October 14, 2022
ANMS is accepting grant applications as part of the ANMS Discovery Grants Program. We will provide support for senior GI fellows, postdoctoral research fellows, or Instructor/Assistant Professor-level faculty who are pursuing research careers in the area of neurogastroenterology and GI motility. Up to two grants of up to $30,000 each will be awarded in 2023 for qualified applicants including senior GI fellows, postdoctoral research fellows, or junior faculty (with no prior or current independent grant funding, i.e. PI status on an R level grant) pursuing projects spanning basic science, translational investigation, and clinical research pertaining to neurogastroenterology and GI motility.
Applicants must be members of the ANMS at the time of application and also the mentors must be ANMS members. The application deadline is October 14, 2022 Applicants will be notified on the outcome of their application by mid-January 2023 and the award period will begin March 1, 2023. Click here for more information and to submit your on-line application.
Objective: To assist promising trainee and junior faculty investigators in carrying out research projects in the area of neurogastroenterology and motility. The ANMS welcomes applications related to a broad range of topics and research methodologies that are relevant to this field. These grants are intended to support investigators generate sufficient preliminary data to obtain extramurally-funded research grants and to promote career development in the area of neurogastroenterology and motility.
Description: The ANMS Discovery Grants will provide support for senior GI fellows, postdoctoral research fellows, or Instructor/Assistant Professor-level faculty who are pursuing research careers in the area of neurogastroenterology and GI motility. Up to two grants of up to $30,000 each will be awarded in 2023 for qualified applicants including senior GI fellows, postdoctoral research fellows, or junior faculty (with no prior or current independent grant funding, i.e. PI status on an R level grant) pursuing projects spanning basic science, translational investigation, and clinical research pertaining to neurogastroenterology and GI motility. Grant applications should clearly describe how investigators intend to use the pilot data for future studies, how the work will enhance applications for extramural research funding, and where the work fits within their overall career goals.
Eligibility: Applicants must be a GI fellow trainee, post-doctoral research fellow, or a faculty member at the Instructor or Assistant Professor level with a primary appointment at an academic institution. Applicants must also be a member or trainee member of the ANMS at the time of application, and mentors must also be an ANMS member. Information on becoming a member of the ANMS can be found at www.motilitysociety.org. It is anticipated that successful candidates will maintain their membership with the ANMS.
Applications will be evaluated by members of the Research Committee.
The American Neurogastroenterology and Motility Society (ANMS) Research Committee is launching a Mentoring Program in Neurogastroenterology and Motility to help young clinicians and scientists (MDs, PhDs, or DVMs) as they start their research career in the areas of neurogastroenterology and gastrointestinal motility. The areas of interest can be varied and the research may take the form of clinical investigation, basic science research, or translational science research. The objective of the program is to provide guidance to individuals at an early stage of their career who may enter the field of neurogastroenterology and gastrointestinal motility.
Manuscripts Sponsored by ANMS on Clinical Topics in GI Motility
Jason R. Baker, Bryan F. Curtin, Baharak Moshiree, Satish S. C. Rao
Organizing and Developing a GI Motility Lab in Community Practice: Challenges and Rewards
Current Gastroenterology Reports, Springer, June 2022, https://doi.org/10.1007/s11894-022-00838-5
Training in gastrointestinal motility.
Dig Dis. 2006;24(3-4):221-7.
Murray JA, Clouse RE, Conklin JL.
Components of the standard esophageal manometry.
Neurogastroenterology and Motility 2003;15(6):591-606.
Gastroesophageal Reflux Disease.
N Engl J Med 2008;359:1700-7.